In the men's category, World's number two Novak Djokovic defeated Japan's Tatsuma Ito 6–1, 6–4, 6–2 to enter the third round of the Australian Open. Defending champion Naomi Osaka defeated Zheng Saisai of China 6-2, 6-4 to enter the next round of this tournament. She will now face 15-year-old Coco Gauff. Coco defeated veteran Sorana Cirstia 4-6 6-3 7-5. She also defeated seven-time Grand Slam champion, Venus Williams at Wimbledon last year. At the same time, 2019 runner-up Petra Kvitova defeated Paula Badosa 7-5, 7-5 to advance to the next round.

Former world number one Caroline Wozniacki defeated Ukraine's Dayana Yastremska 7-5, 7-5. World number one player Ashleigh Barty of Australia defeated Polona Hercog 6–1, 6–4. Eight matches of the first round of the women's singles category could not be held on Tuesday as several matches were suspended due to rain on Monday.

Fourteenth-ranked Sofia Kenin, 18th-ranked Allison Riske, 25th-ranked Ekaterina Alexandrova and Julia Georges also advanced to the next round. Julia defeated 13th seed Petra Martic 4-6 6-3 7-5. In the first round match Carla Suarez Navarro defeated 11th seed Aryna Sabalenka 7-6, 7-6. At the same time, Taylor defeated America's Jessica Pegula 6-4, 7-6.