AIIMS has identified two biomarkers that will make it possible to detect damage in the intestine of a patient with Celiac disease. Actually, celiac is a disease in which the body gets immunity from eating protein gluten found in wheat which causes damage to the small intestine.
Assessment of loss due to biopsy
So far, in this disease, a biopsy has to be done to assess the damage done to the villous in the intestine, in which the patient has a lot of pain and also takes a lot of time. Now only 2 blood tests will know the damage done to the intestine. With this, treatment of the patient will be possible quickly and easily.
Villous helps to digest food
The villous is a functional unit inside the intestine, which helps digest food. Dr. Govind Makharia of AIIMS's Gastroenterology Department said that celiac is a disease that triggers an immune response in the small intestine due to the gluten found in wheat. But many times this disease causes damage to the villous inside the intestine and it is not known because the damage to the villous is detected only when the patient undergoes biopsy.
Only 2 blood tests will reveal the damage
Biopsy is a bit difficult examination, for this endoscopy is done and this machine goes inside the stomach through the mouth, then the process is complete. Therefore, most people do not want this test. The solution to this problem is now out. Now only 2 blood tests will know whether the villous present in the patient's intestine is damaged or not. Doctor Alka Singh, who was involved in this study in AIIMS, said that we did a comparative study for this and then came to tStudy done through 3 different groups
Three types of groups were included in this study. The first 131 patients suffering from celiac disease were taken. In the second group, there were 216 people who did not have any kind of disease. In the third group 133 such people were taken who were not suffering from celiac disease but they were not completely healthy. We then used a biomarker to detect the disease inside them, in which Citrulline and FABP were investigated. Doctor Alka said that a range has been defined for this, if the report comes within that range then the damage caused to the villous can be detected. This investigation will be helpful for doctors across the country involved in the treatment of this disease.
